The contamination of As can be propagated defectively into the groundwater system because As in groundwater and aquifers is mobilized (e.g., hydraulic fracturing). Hence, its contamination can affect a large population of people. Groundwater concentration of As has been documented in the literature which reveals a very large range from less than 0.5 to 5000 ppb covering natural As contamination found in more than 70 countries. Some of the best reported and most severe cases of arsenic contaminated groundwater have been found in aquifers across the globe. It represents that provisional guideline values for As concentration in groundwater are commonly set at 10 ppb, although it can reach up to 50 ppb. The outcomes of this comparison affirm that As contamination is a widespread global phenomenon and severe enough exceeding such guideline values. In fact, people consuming As-rich water for prolonged periods are reported to suffer from serious health problems in many parts of the world.